Teratogenicity of patulin and patulin adducts formed with cysteine.
نویسندگان
چکیده
The mean lethal dose of patulin for the chicken embryo injected in the air cell before incubation was determined to be 68.7 mug and that for the 4-day-old embryo was 2.35 mug. Both patulin (1 to 2 mug/egg) and the reaction mixture between patulin and cysteine (15 to 150 mug of patulin equivalents) were teratogenic to the chicken embryo. At least two ninhydrin-negative and four ninhydrin-positive products were formed during the latter reaction. Our explanation of the reaction mechanism remains to be elaborated.
منابع مشابه
Antimicrobial activity of patulin derivatives: a preliminary report.
Preliminary results are reported of antimicrobial assays conducted with chemically synthesized derivatives of patulin, a mycotoxin produced by several species of Penicillia and Aspergilli. Patulin (Fig. 1) has been shown to be an antibiotic1) and a carcinogen2); it is considered too toxic for humans or animals3) and is inhibitory to plants4). It is an a,R-unsaturated r-lactone with two conjugat...
متن کاملPatulin contamination in apple products marketed in Shiraz, Southern Iran
Background and Purpose: Patulin is one of the important mycotoxins, produced by a wide range of molds, including Penicillium, Aspergillus, and Bysochlamys. Patulin is mainly found in the rotten parts of fruits and vegetables, such as apples, pears, peach, apricots, and grapes. Currently, the Codex Alimentarius and Food and Drug Administration have recommended a maximum level of 50 μg/L patul...
متن کاملبررسی توانایی نانوذرات سلولز کونژوگه شده با پلی‌گوانین در جذب سم پاتولین در آب سیب‌های آلوده
Abstract Introdction: Patulin is a dangerous toxin produced by various fungi. Hence, the current study aimed to evaluate adsorption of Patulin by nanocellulose conjugated with Poly-guanine in contaminated apple juice. Methods: Firstly, nanocellulose was synthesized, and then it was bonded to poly-guanine by a cross-linker. Then, concentration serial of Patulin was prepared in the apple ju...
متن کاملEffective Biodegradation of Mycotoxin Patulin by Porcine Pancreatic Lipase
Patulin is a common contaminant in fruits and vegetables, which is difficult to remove. In this study, the biodegradation of patulin using porcine pancreatic lipase (PPL) was investigated. The method of HPLC was used to analyze the concentration of patulin. Batch degradation experiments were performed to illustrate the effect of PPL amount, pH, temperature, contact time, and initial concentrati...
متن کاملIn vitro antitumor activity of patulin on cervical and colorectal cancer cell lines
Background and Purpose: Patulin is a mycotoxin produced by some molds,especially Aspergillus and Penicilium, and is responsible for mycotoxicosis in animals and humans.There is still not very detailed data about the anti-cancer potency of patulin, but some reports demonstrated that it induces cellular apoptosis and toxicity. Materials and Methods: To determine the efficacy of patulin as a ther...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Applied and environmental microbiology
دوره 31 5 شماره
صفحات -
تاریخ انتشار 1976